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In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression

Taken together, these studies suggest that adult NC-derived MSCs, particularly GMSCs, represent a promising source of Schwann-like cells for cell-based regenerative therapy of PNIs

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The study aims to determine the degree of weight reduction and the frequency of adverse events at different doses

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